منابع مشابه
Immunosuppression and Malignancy
The increasing use over the past decade of powerful immunosuppressive drugs provides an opportunity for testing the validity of the theory that cancer results from a breakdown of the body's "immunological surveillance." This concept, first proposed by L. Thomas' and since developed by Sir Macfarlane Burnet,2 holds that such a breakdown allows the proliferation of abnormal cells, with the eventu...
متن کاملIMMUNOSUPPRESSION IN HUMAN UTERINE TISSUES THROUGHOUT THE REPRODUCTIVE CYCLE
The purpose of this study was to investigate and compare whether the explant supernatants prepared from endometrial tissues during the proliferative phase, secretory phase and early pregnancy differ in immunosuppressive activity. Specimens of nonpregnant endometrium from hysterectomies and normal first trimester decidua following elective aspiration termination of pregnancy were obtained. ...
متن کاملOncogenic genes and human malignancy.
All vertebrates possess a series of genes which are homologs of the oncogenic genes of acute transforming retroviruses. Two lines of evidence suggest that these genes may play a role in the development of human malignancy: (1) DNA from a variety of human tumors transforms NIH 3T3 mouse fibroblasts and the transforming genes from a number of carcinomas, sarcomas, and hematological malignancies h...
متن کاملImmunocompetence, Immunosuppression, and Human Breast Cancer
Comprehensive immune function by integrated score was assessed in 158 operable, 55 inoperable, and 52 metastatic breast cancer patients relative to 107 healthy controls. The score was derived from in vivo response to PPD and DNCB and in vitro lymphocyte stimulation by PPD and PHA. Proportion of E-RFC was significantly lower in patients than in controls but was not found to correlate directly wi...
متن کاملImmunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients.
The success of renal transplantation may be counterbalanced by serious adverse medical events. The effect of immunosuppression on the incidence of de novo neoplasms among kidney recipients should be monitored continuously. Using data from the Scientific Registry of Transplant Recipients, we studied the association of induction therapy by immunosuppression with antilymphocyte antibodies, with th...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1990
ISSN: 0021-9746
DOI: 10.1136/jcp.43.9.785-b